Profesionalitas Aparatur Sekretariat Daerah di Kabupaten Sumbawa Besar

The aim of this research is knowing the profesionality of aparature at local secretary of Sumbawa region in doing their work depend on function and job description. Beside that, this research try to know some obstacles and find the solution to increase aparature profesionality at Sekretariat Daerah Kabupaten Sumbawa. This reseachs title is a Profesionality of aparature at local secretary of Sumbawa region. Research methods is used descriptive survey, documentation, Questioner, interview. The respondents of this research are civil servant at Sekretariat Daerah Kabupaten Sumbawa. From this research knew that civil servant competency is good, Acuntability is good, Recruitment is fair, Education level is poor. The conclution is aparatures profesionality at local secretary of Sumbawa region in fair level. Keywords: Profesionality, Local secretary, Sumbawa Regio

“Where Are We Now?” The Image Construction of Arabs and Muslims in Bodyguard

Over the past decade Arab and Muslim representations in the media have been either negative or overly simplified as a way to avoid criticism from watchdog groups. Arab and Muslim culture is viewed by the mainstream Western perspective as different, and inferior. According to Edward Said this divide and hierarchy between Eastern and Western comes through the process of Othering and is at the heart of Orientalism. This thesis investigates how Arabs and Muslims are Othered through a case study of the successful BBC television series Bodyguard. Bodyguard presents the British government and police force attempting to stop various terrorist attacks in London by Arab Muslims. I analyze the representation of the four Muslim males and one female on the show in juxtaposition with the lead character of Sargent David Budd. Here, Budd is presented as the white savior in that he is trying to save the subservient, obedient Muslim wife of the terrorist (Nadia). I also heavily focus on the analysis of Nadia\u27s character and highlight how she is Othered in different stages of her character development. Her Othering starts by representing her as passive, obedient, wears the hijab, and mostly silent, and ends with her being diabolical and evil. This representation, which I identify as the Duplicitous Arab or Muslim, may implicitly or explicitly present the idea that even when Arabs and Muslims seem trustworthy they are not

Sulphatisation and Sulphidisation for hydro-metallurgical extraction of main constituents of a local ilmenite Ore

ILMENITE ores occur in UAR in large quantities, const- ituting two main reserves . The first, estimated to be about 10 million tons, occurs at Abu Ghalaga (AG) in the south-eastern desert, and the second comprises one of the chief constituents of beach placers, called black sands (BS), which are deposited on the shores of the Nile delta, especially at Rosetta and El-Arish. According to previous studies' AG ilmenite occurs in the form of lenticular , vein-like bodies intimately associated with metagabbro. The chief lens is about 300 m long, 150 m wide and 45 to 100 m thick

Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos.

Asymmetric positioning of the mitotic spindle in C. elegans embryos is mediated by force-generating complexes that are anchored at the plasma membrane and that pull on microtubules growing out from the spindle poles. Although asymmetric distribution of the force generators is thought to underlie asymmetric positioning of the spindle, the number and location of the force generators has not been well defined. In particular, it has not been possible to visualize individual force generating events at the cortex. We discovered that perturbation of the acto-myosin cortex leads to the formation of long membrane invaginations that are pulled from the plasma membrane toward the spindle poles. Several lines of evidence show that the invaginations, which also occur in unperturbed embryos though at lower frequency, are pulled by the same force generators responsible for spindle positioning. Thus, the invaginations serve as a tool to localize the sites of force generation at the cortex and allow us to estimate a lower limit on the number of cortical force generators within the cell

Time trends and trophic transfer of polybrominated diphenylethers (PBDEs) in Antarctic biota

Polybrominated diphenyl ethers (PBDEs) are “emerged” contaminants that were produced and used as flame retardants in numerous consumer and industrial applications for decades until banned. They remain ubiquitously present in the environment today. Here, a unique set of \u3e200 biotic samples from the Antarctic was analyzed for PBDEs, including phytoplankton, krill, fish, and fur seal milk, spanning several sampling seasons over 14 years. PBDE-47 and -99 were the dominant congeners determined in all samples, constituting \u3e60% of total PBDEs. A temporal trend was observed for ∑7PBDE concentrations in fur seal milk, where concentrations significantly increased (R2 = 0.57, p \u3c 0.05) over time (2000–2014). Results for krill and phytoplankton also suggested increasing PBDE concentrations over time. Trends of PBDEs in fur seal milk of individual seals sampled 1 or more years apart showed no clear temporal trends. Overall, there was no indication of PBDEs decreasing in Antarctic biota yet, whereas numerous studies have reported decreasing trends in the northern hemisphere. Similar PBDE concentrations in perinatal versus nonperinatal milk implied the importance of local PBDE sources for bioaccumulation. These results indicate the need for continued assessment of contaminant trends, such as PBDEs, and their replacements, in Antarctica

Spatial Distribution, Air-Water Fugacity Ratios and Source Apportionment of Polychlorinated Biphenyls in the Lower Great Lakes Basin

Polychlorinated biphenyls (PCBs) continue to be contaminants of concern across the Great Lakes. It is unclear whether current concentrations are driven by ongoing primary emissions from their original uses, or whether ambient PCBs are dominated by their environmental cycling. Freely dissolved PCBs in air and water were measured using polyethylene passive samplers across Lakes Erie and Ontario during summer and fall, 2011, to investigate their spatial distribution, determine and apportion their sources and to asses their air–water exchange gradients. Average gaseous and freely dissolved ∑29 PCB concentrations ranged from 5.0 to 160 pg/m3 and 2.0 to 55 pg/L respectively. Gaseous concentrations were significantly correlated (R2 = 0.80) with the urban area within a 3−20 km radius. Fugacity ratios indicated that the majority of PCBs are volatilizing from the water thus acting as a secondary source for the atmosphere. Dissolved PCBs were probably linked to PCB emissions from contaminated sites and areas of concern. Positive matrix factorization indicated that although volatilized Aroclors (gaseous PCBs) and unaltered Aroclors (dissolved PCBs) dominate in some samples, ongoing non-Aroclor sources such as paints/pigments (PCB 11) and coal/wood combustion showed significant contributions across the lower Great Lakes. Accordingly, control strategies should give further attention to PCBs emitted from current use sources

Preventing arrhythmic death in patients with tetralogy of Fallot JACC review topic of the week

Patients with tetralogy of Fallot are at risk for ventricular arrhythmias and sudden cardiac death. These abnormalities are associated with pulmonary regurgitation, right ventricular enlargement, and a substrate of discrete, slowly-conducting isthmuses. Although these arrhythmic events are rare, their prediction is challenging. This review will address contemporary risk assessment and prevention strategies. Numerous variables have been proposed to predict who would benefit from an implantable cardioverter-defibrillator. Current risk stratification models combine independently associated factors into risk scores. Cardiac magnetic resonance imaging, QRS fragmentation assessment, and electrophysiology testing in selected patients may refine some of these models. Interaction between right and left ventricular function is emerging as a critical factor in our understanding of disease progression and risk assessment. Multicenter studies evaluating risk factors and risk mitigating strategies such as pulmonary valve replacement, ablative strategies, and use of implantable cardiac-defibrillators are needed moving forward. (c) 2021 by the American College of Cardiology Foundation.Cardiolog

Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-jB signaling and IL-8 expression

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. The transcription factor NF-κB is overexpressed in human MB and is a critical factor for MB tumor growth. NF-κB is known to regulate the expression of interleukin-8 (IL-8), the chemokine that enhances cancer cell growth and resistance to chemotherapy. We have recently shown that thymoquinone (TQ) suppresses growth of hepatocellular carcinoma cells in part by inhibiting NF-κB signaling. Here we sought to extend these studies in MB cells and show that TQ suppresses growth of MB cells in a dose- and time-dependent manner, causes G2M cell cycle arrest, and induces apoptosis. TQ significantly increased generation of reactive oxygen species (ROS), while pretreatment of MB cells with the ROS scavenger N-acetylcysteine (NAC) abrogated TQ-induced cell death and apoptosis, suggesting that TQ-induced cell death and apoptosis are oxidative stress-mediated. TQ inhibitory effects were associated with inhibition of NF-κB and altered expression of its downstream effectors IL-8 and its receptors, the anti-apoptotic Bcl-2, Bcl-xL, X-IAP, and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9, Bcl-xS, and cytochrome c. TQ-triggered apoptosis was substantiated by up-regulation of the executioner caspase-3 and caspase-7, as well as cleavage of the death substrate poly(ADP-ribose)polymerase. Interestingly, pretreatment of MB cells with NAC or the pan-caspase inhibitor zVAD-fmk abrogated TQ-induced apoptosis, loss of cyclin B1 and NF-κB activity, suggesting that these TQ-mediated effects are oxidative stress- and caspase-dependent. These findings reveal that TQ induces both extrinsic and intrinsic pathways of apoptosis in MB cells, and suggest its potential usefulness in the treatment of MB

Effect of Metabolizable Energy and Crumble Quality of the Diet on Growth Performance of Broilers

In order to optimize the growth performance of broilers, diets are formulated to a recommended ME concentration. In addition, broilers (chicks) are often fed diets in the form of crumbles in early production to improve growth performance. Thus, the objective of this study was to determine the effect of ME concentration in diets and if removal of crumble fines influenced the growth performance response of broilers. At hatch, a total of 300 one-day-old male broilers (Cobb 500, initial BW 0.093 lb) were used in an 18-day study. Broilers were housed in 3 Petersime batteries with ad libitum access to feed and water. Treatments were randomly assigned to 60 cages balanced by location, resulting in 10 cages per treatment with 5 broilers per cage. Treatments were arranged in a 2 × 3 factorial of ME content (1,376 and 1,346 ME, kcal/lb) and crumbled diets with or without fines (removed particles \u3c 1,532 µm or \u3c 864 µm). Crumble treatments were fed with no sifting (NS) or sifted using either a screen with 0.06-in. openings (removed particles \u3c 1,532 µm) or a screen with 0.03-in. openings (removed particles \u3c 864 µm). Data were analyzed as a completely randomized design using the GLIMMIX procedure of SAS (v. 9.4, SAS Institute, Inc., Cary, NC). There was no evidence of an interaction between crumble fines removal and ME or main effect of ME. Body weight gain (BWG) and total feed intake (TFI) increased (P \u3c 0.05) when broilers were fed crumbles sifted with a 0.06-in. screen compared to NS and crumbles sifted with a 0.03-in. screen. Broiler feed conversion ratio (FCR) improved (P \u3c 0.001) when broilers were fed crumbles sifted with a 0.06-in. screen compared to those fed NS and sifted with a 0.03-in. screen. In conclusion, broilers fed crumbles with particles \u3c 1,532 µm removed had an improved FCR and an increased BWG and TFI regardless of the ME content of the diet. Increasing ME from 1,346 to 1,376 kcal/lb did not influence growth performance of broilers from d 0 to 18 d of age

Growth Performance of Broilers in Response to Increasing Concentration of Multiple Mycotoxins in Contaminated Corn

Mycotoxins in grains are a result of mold or fungal growth from environmental stressors and cause detrimental impacts to poultry production. Thus, the objective of this experiment was to determine the effects of increasing concentration of a combina­tion of mycotoxins on growth performance of broiler chicks. A total of 250 one-day-old male broilers (Cobb 500; initial BW 0.092 lb) were used in a 15-d study. Broilers were housed in 3 Petersime batteries with ad libitum access to feed and water. Treatments were randomly assigned to 1 of 50 cages within location block, resulting in 10 cages per treatment with 5 broilers per cage balanced by BW. For this experiment, the sourced contaminated corn contained 8.2 ppm fumonisin (FUM), 8.0 ppm deoxynivalenol (DON), and 551 ppb zearalenone (ZEA). Dietary treatments consisted of 0%, 25%, 50%, 75%, and 100% of the mycotoxin contaminated corn replacing non-contaminated corn. The resulting complete diet mycotoxin concentrations were 1.5 ppm, 1.4 ppm, 2.3 ppm, 2.9 ppm, and 3.9 ppm for FUM; \u3c 0.6 ppm, 1.0 ppm, 1.4 ppm, 2.3 ppm, and 3.0 ppm for DON; and \u3c 51.7 ppb, 94.5 ppb, 180.5 ppm, 294.6 ppb, and 364.1 ppb for ZEA, respectively. Data were analyzed as a completely randomized design with cage as the experimental unit using the GLIMMIX procedure of SAS 9.4 (Cary, NC). Results were considered significant at P ≤ 0.05. Total body weight gain (BWG) decreased (linear, P = 0.007) and feed intake (FI) tended to decrease (linear, P = 0.093) in broilers fed diets with increasing concentration of mycotoxin contaminated corn in the diet. The increase in mycotoxin concentration in diets fed to broilers also resulted in poorer (linear, P = 0.010) feed conversion ratio (FCR). In conclusion, increasing concentra­tions of FUM, DON, and ZEA in broiler feed negatively impacted BWG, FI, and FCR even when the mycotoxin levels were below acceptable limits for individual mycotoxins